5Z4P

Crystal structure of tubulin-stathmin-TTL-Compound TCA complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Tubulin alpha-1B chain	polymer	440	48966.3	2	UniProt (P81947) Pfam (PF00091) Pfam (PF03953)	Bos taurus (Bovine)	Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
2	B, D (B, D)	Tubulin beta-2B chain	polymer	431	48391.4	2	UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953)	Bos taurus (Bovine)
3	E (E)	Stathmin-4	polymer	185	21680.8	1	UniProt (P63043) Pfam (PF00836)	Rattus norvegicus (Rat)	Stathmin-like protein B3,RB3
4	F (F)	Tubulin tyrosine ligase	polymer	378	43549.6	1	UniProt (E1BQ43)	Gallus gallus (Chicken)
5	G, U (A, C)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP)
6	EA, H, N, V (D, A, B, C)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
7	FA, GA, I, J, L... (D, A, B, C)	GLYCEROL	non-polymer		92.1	11	Chemie (GOL)
8	K, P, Z (A, B, C)	CALCIUM ION	non-polymer		40.1	3	Chemie (CA)
9	DA, M (D, B)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
10	Q (B)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)
11	R (B)	6,7,8-trimethoxy-1-(4-methoxyphenyl)-4,5-dihydro-2~{H}-benzo[e]indazole	non-polymer		366.4	1	Chemie (97O)
12	AA, BA, CA (C)	IMIDAZOLE	non-polymer		69.1	3	Chemie (IMD)
13	HA (F)	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	1	Chemie (ACP)
14	IA, JA, KA, LA, MA (A, B, C, D, F)	water	water		18.0	52	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	259945.9
Non-Polymers*	Number of molecules	28
	Total formula weight	4437.4
All*	Total formula weight	264383.3

*Water molecules are not included.