5Z1E
MAP2K7 C218S mutant-inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity mitogen-activated protein kinase kinase 7 | polymer | 324 | 36982.8 | 1 | UniProt (O14733) Pfam (PF00069) | Homo sapiens (Human) | MAPKK 7,JNK-activating kinase 2,MAPK/ERK kinase 7,MEK 7,Stress-activated protein kinase kinase 4,SAPKK4,c-Jun N-terminal kinase kinase 2,JNKK 2 |
| 2 | B (A) | N-[3-(6-methyl-1H-indazol-3-yl)phenyl]prop-2-enamide | non-polymer | 277.3 | 1 | Chemie (95U) | |||
| 3 | C (A) | water | water | 18.0 | 116 | Chemie (HOH) |
Sequence modifications
A: 119 - 435 (UniProt: O14733)
| PDB | External Database | Details |
|---|---|---|
| Met 118 | - | initiating methionine |
| Ser 218 | Cys 202 | conflict |
| His 436 | - | expression tag |
| His 437 | - | expression tag |
| His 438 | - | expression tag |
| His 439 | - | expression tag |
| His 440 | - | expression tag |
| His 441 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36982.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 277.3 | |
| All* | Total formula weight | 37260.2 |
