5YWY
Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and ONO-AE3-208
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Prostaglandin E2 receptor EP4 subtype,Prostaglandin E2 receptor EP4 subtype | polymer | 332 | 37063.5 | 1 | UniProt (P35408) Pfam (PF00001) | Homo sapiens (Human) | PGE2 receptor EP4 subtype,Prostanoid EP4 receptor |
| 2 | B (H) | Heavy chain of Fab fragment | polymer | 253 | 27574.1 | 1 | Mus musculus (Mouse) | FabH | |
| 3 | C (L) | Light chain of Fab fragment | polymer | 236 | 26614.9 | 1 | Mus musculus (Mouse) | FabL | |
| 4 | D (A) | 4-[4-cyano-2-[[(2R)-2-(4-fluoranylnaphthalen-1-yl)propanoyl]amino]phenyl]butanoic acid | non-polymer | 404.4 | 1 | Chemie (7UR) |
Sequence modifications
A: 4 - 259 (UniProt: P35408)
A: 260 - 366 (UniProt: P35408)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Thr 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Gln 7 | Asn 7 | engineered mutation |
| Leu 62 | Ala 62 | engineered mutation |
| Arg 106 | Gly 106 | engineered mutation |
| Gln 177 | Asn 177 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Leu 367 | - | expression tag |
| Glu 368 | - | expression tag |
| Glu 369 | - | expression tag |
| Asn 370 | - | expression tag |
| Leu 371 | - | expression tag |
| Tyr 372 | - | expression tag |
| Phe 373 | - | expression tag |
| Gln 374 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 91252.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 404.4 | |
| All* | Total formula weight | 91656.9 |
