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5YVG

Crystal structure of Karyopherin beta2 in complex with FUS(full length)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Transportin-1polymer86898325.42UniProt (Q92973)
Pfam (PF03810)
Pfam (PF02985)
Pfam (PF13513)
Homo sapiens (Human)Importin beta-2,Karyopherin beta-2,M9 region interaction protein,MIP
2C, D
(X, Y)
RNA-binding protein FUSpolymer52853623.82UniProt (P35637)
Pfam (PF00076)
Pfam (PF00641)
Homo sapiens (Human)75 kDa DNA-pairing protein,Oncogene FUS,Oncogene TLS,POMp75,Translocated in liposarcoma protein
Sequence modifications
A, B: 1 - 360 (UniProt: Q92973)
PDBExternal DatabaseDetails
Gly -1-expression tag
Ser 0-expression tag
A, B: 368 - 890 (UniProt: Q92973)
PDBExternal DatabaseDetails
Gly 361-linker
Gly 362-linker
Ser 363-linker
Gly 364-linker
Gly 365-linker
Ser 366-linker
Gly 367-linker
X, Y: 1 - 526 (UniProt: P35637)
PDBExternal DatabaseDetails
Gly -1-expression tag
Ser 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight303898.3
All*Total formula weight303898.3
*Water molecules are not included.

246031

PDB entries from 2025-12-10

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