5YSU
Plumbagin in complex with CRM1-RanM189D-RanBP1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | GTP-binding nuclear protein Ran | polymer | 216 | 24440.0 | 1 | UniProt (P62826) Pfam (PF00071) In PDB | Homo sapiens (Human) | Androgen receptor-associated protein 24,GTPase Ran,Ras-like protein TC4,Ras-related nuclear protein |
| 2 | B | Ran-specific GTPase-activating protein 1 | polymer | 140 | 16320.7 | 1 | UniProt (P41920) Pfam (PF00638) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Chromosome stability protein 20,Perinuclear array-localized protein,Ran-binding protein 1,RANBP1 |
| 3 | C | Exportin-1,Exportin-1 | polymer | 1024 | 117442.8 | 1 | UniProt (P30822) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Chromosome region maintenance protein 1,Karyopherin-124,Chromosome region maintenance protein 1,Karyopherin-124 |
| 4 | A | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 5 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | A, C | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 7 | A, C | NITRATE ION | non-polymer | 62.0 | 4 | Chemie (NO3) | |||
| 8 | C | (2~{R})-2-methyl-5-oxidanyl-2,3-dihydronaphthalene-1,4-dione | non-polymer | 190.2 | 2 | Chemie (F2X) | |||
| 9 | C | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 10 | water | water | 18.0 | 348 | Chemie (HOH) |
Sequence modifications
A: 1 - 216 (UniProt: P62826)
C: 1 - 376 (UniProt: P30822)
C: 414 - 1058 (UniProt: P30822)
| PDB | External Database | Details |
|---|---|---|
| Asp 189 | Met 189 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 537 | Asp 537 | engineered mutation |
| Cys 539 | Thr 539 | engineered mutation |
| Glu 540 | Val 540 | engineered mutation |
| Gln 541 | Lys 541 | engineered mutation |
| Cys 1022 | Tyr 1022 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 158203.5 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1269.8 | |
| All* | Total formula weight | 159473.3 |
