5YQL
Crystal structure of Sirt2 in complex with selective inhibitor A2I
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | NAD-dependent protein deacetylase sirtuin-2 | polymer | 306 | 34449.7 | 1 | UniProt (Q8IXJ6) Pfam (PF02146) In PDB | Homo sapiens (Human) | Regulatory protein SIR2 homolog 2,SIR2-like protein 2 |
| 2 | A | 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[3-(phenoxymethyl)phenyl]ethanamide | non-polymer | 379.5 | 1 | Chemie (A2I) | |||
| 3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | A | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 2 | Chemie (BME) | |||
| 5 | water | water | 18.0 | 382 | Chemie (HOH) |
Sequence modifications
A: 56 - 356 (UniProt: Q8IXJ6)
| PDB | External Database | Details |
|---|---|---|
| Gly 51 | - | expression tag |
| Ala 52 | - | expression tag |
| Ser 53 | - | expression tag |
| Gly 54 | - | expression tag |
| Ser 55 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34449.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 601.1 | |
| All* | Total formula weight | 35050.8 |
