5YE9
The crystal structure of Lp-PLA2 in complex with a novel inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Platelet-activating factor acetylhydrolase | polymer | 388 | 43905.8 | 2 | UniProt (Q13093) Pfam (PF03403) | Homo sapiens (Human) | Lp-PLA2,PAF acetylhydrolase,1-alkyl-2-acetylglycerophosphocholine esterase,2-acetyl-1-alkylglycerophosphocholine esterase,Group-VIIA phospholipase A2,gVIIA-PLA2,LDL-associated phospholipase A2,LDL-PLA(2),PAF 2-acylhydrolase |
| 2 | C, G (A, B) | N-[4-[(3-cyano-4-naphthalen-2-yloxy-phenyl)sulfamoyl]phenyl]ethanamide | non-polymer | 457.5 | 2 | Chemie (8U6) | |||
| 3 | D, E, F (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 223 | Chemie (HOH) |
Sequence modifications
A, B: 47 - 429 (UniProt: Q13093)
| PDB | External Database | Details |
|---|---|---|
| Gly 42 | - | expression tag |
| Pro 43 | - | expression tag |
| Leu 44 | - | expression tag |
| Gly 45 | - | expression tag |
| Ser 46 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 87811.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1203.2 | |
| All* | Total formula weight | 89014.8 |
