5Y8C

Crystal Structure Analysis of the BRD4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Bromodomain-containing protein 4	polymer	139	16509.1	1	UniProt (O60885) Pfam (PF00439)	Homo sapiens (Human)	Protein HUNK1
2	B, C (A)	NITRATE ION	non-polymer		62.0	2	Chemie (NO3)
3	D (A)	5-chloranyl-2-methoxy-N-(6-methoxy-3-methyl-1,2-benzoxazol-5-yl)benzenesulfonamide	non-polymer		382.8	1	Chemie (8P9)
4	E, F (A)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
5	G (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	H (A)	water	water		18.0	60	Chemie (HOH)

Sequence modifications

A: 44 - 166 (UniProt: O60885)

PDB	External Database	Details
Met 28	-	expression tag
Lys 29	-	expression tag
Lys 30	-	expression tag
Gly 31	-	expression tag
His 32	-	expression tag
His 33	-	expression tag
His 34	-	expression tag
His 35	-	expression tag
His 36	-	expression tag
His 37	-	expression tag
Leu 38	-	expression tag
Val 39	-	expression tag
Pro 40	-	expression tag
Arg 41	-	expression tag
Gly 42	-	expression tag
Ser 43	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	16509.1
Non-Polymers*	Number of molecules	6
	Total formula weight	723.1
All*	Total formula weight	17232.2

*Water molecules are not included.