5Y3J

Crystal structure of horse TLR9 in complex with two DNAs (CpG DNA and TCGCAC DNA)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Toll-like receptor 9	polymer	802	89427.6	2	UniProt (Q2EEY0) Pfam (PF13516) Pfam (PF00560) Pfam (PF13855) Pfam (PF18837)	Equus caballus (Horse)
2	C, E (C, D)	DNA (5'-D(*AP*GP*GP*CP*GP*TP*TP*TP*TP*T)-3')	polymer	10	3066.0	2		synthetic construct
3	D, F (E, F)	DNA (5'-D(*TP*CP*GP*CP*AP*C)-3')	polymer	6	1769.2	2		synthetic construct
4	G, H (G, H)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	I, J, K, L, M... (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	15	Chemie (NAG)
6	Q, Y (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
7	AA, BA, CA, DA, EA... (B, C, E, D, F...)	water	water		18.0	2078	Chemie (HOH)

Sequence modifications

A, B: 26 - 819 (UniProt: Q2EEY0)

PDB	External Database	Details
Arg 22	-	expression tag
Ser 23	-	expression tag
Pro 24	-	expression tag
Trp 25	-	expression tag
Glu 818	Cys 818	conflict
Leu 820	-	expression tag
Val 821	-	expression tag
Pro 822	-	expression tag
Arg 823	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	188525.5
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	17
	Total formula weight	3366.7
All*	Total formula weight	192741.1

*Water molecules are not included.