5Y2T

Structure of PPARgamma ligand binding domain - lobeglitazone complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Peroxisome proliferator-activated receptor gamma	polymer	294	33376.6	2	UniProt (P37231) Pfam (PF00104)	Homo sapiens (Human)	PPAR-gamma,Nuclear receptor subfamily 1 group C member 3
2	C, D (A, B)	(5S)-5-[[4-[2-[[6-(4-methoxyphenoxy)pyrimidin-4-yl]-methyl-amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione	non-polymer		480.5	2	Chemie (8LX)
3	E, F (A, B)	water	water		18.0	453	Chemie (HOH)

Sequence modifications

A, B: 207 - 477 (UniProt: P37231)

PDB	External Database	Details
Met 184	-	expression tag
Gly 185	-	expression tag
Ser 186	-	expression tag
Ser 187	-	expression tag
His 188	-	expression tag
His 189	-	expression tag
His 190	-	expression tag
His 191	-	expression tag
His 192	-	expression tag
His 193	-	expression tag
Ser 194	-	expression tag
Ser 195	-	expression tag
Gly 196	-	expression tag
Leu 197	-	expression tag
Val 198	-	expression tag
Pro 199	-	expression tag
Arg 200	-	expression tag
Gly 201	-	expression tag
Ser 202	-	expression tag
Ala 203	-	expression tag
Met 204	-	expression tag
Gly 205	-	expression tag
Ser 206	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	66753.3
Non-Polymers*	Number of molecules	2
	Total formula weight	961.1
All*	Total formula weight	67714.3

*Water molecules are not included.