5Y2F
Human SIRT6 in complex with allosteric activator MDL-801
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-dependent protein deacetylase sirtuin-6 | polymer | 316 | 35003.1 | 1 | UniProt (Q8N6T7) Pfam (PF02146) | Homo sapiens (Human) | Regulatory protein SIR2 homolog 6,SIR2-like protein 6 |
| 2 | B (C) | 9-mer peptide QTARKSTGG | polymer | 9 | 907.0 | 1 | UniProt (by SIFTS) (P68431) | Homo sapiens | |
| 3 | C (A) | [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | non-polymer | 559.3 | 1 | Chemie (AR6) PubChem (192) PubChem (25113622) PubChem (25113623) PubChem (44415180) PubChem (51051599) PubChem (44144391) PubChem (445794) PubChem (447048) PubChem (89379870) PubChem (33576) PubChem (447165) PubChem (448826) PubChem (91746164) PubChem (9548001) PubChem (9547960) PubChem (122606931) PubChem (122609061) PubChem (10437766) PubChem (174159053) PubChem (140853820) PubChem (146879505) PubChem (162774256) PubChem (162782217) PubChem (163972867) PubChem (173750345) PubChem (173750346) PubChem (175675949) | |||
| 4 | D (A) | 5-[[3,5-bis(chloranyl)phenyl]sulfonylamino]-2-[(5-bromanyl-4-fluoranyl-2-methyl-phenyl)sulfamoyl]benzoic acid | non-polymer | 612.3 | 1 | Chemie (8L9) PubChem (134717373) | |||
| 5 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | F, G, H, I, J (A) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) PubChem (753) | |||
| 7 | K, L, M, N, O... (A, C) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 8 | Q (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) PubChem (8117) | |||
| 9 | R (C) | HEXADECANE-1-SULFINIC ACID | non-polymer | 290.5 | 1 | Chemie (HDR) PubChem (6914363) | |||
| 10 | T, U (A, C) | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35910.1 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 2766.5 | |
| All* | Total formula weight | 38676.6 |
