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5XZE

Mouse cGAS bound to the inhibitor RU332

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ACyclic GMP-AMP synthasepolymer36242512.11UniProt (Q8C6L5)
Pfam (PF03281)
Pfam (PF20266)
In PDB
Mus musculus (Mouse)m-cGAS, 2'3'-cGAMP synthase, Mab-21 domain-containing protein 1
2EDNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*G)-3')polymer154627.01Mus musculus
3FDNA (5'-D(P*CP*GP*TP*CP*TP*TP*CP*GP*GP*CP*AP*AP*TP*T)-3')polymer144246.81Mus musculus
4AZINC IONnon-polymer65.41Chemie (ZN)
5A(3R)-3-[1-(3H-1lambda~4~,3-benzothiazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-2-benzofuran-1(3H)-onenon-polymer365.41Chemie (AE7)
6waterwater18.082Chemie (HOH)
Sequence modifications
A: 147 - 507 (UniProt: Q8C6L5)
PDBExternal DatabaseDetails
Ser 146-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight51385.9
Non-Polymers*Number of molecules2
Total formula weight430.8
All*Total formula weight51816.7
*Water molecules are not included.

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PDB entries from 2024-06-12

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