5XZE
Mouse cGAS bound to the inhibitor RU332
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclic GMP-AMP synthase | polymer | 362 | 42512.1 | 1 | UniProt (Q8C6L5) Pfam (PF03281) Pfam (PF20266) | Mus musculus (Mouse) | m-cGAS, 2'3'-cGAMP synthase, Mab-21 domain-containing protein 1 |
| 2 | B (E) | DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*G)-3') | polymer | 15 | 4627.0 | 1 | Mus musculus | ||
| 3 | C (F) | DNA (5'-D(P*CP*GP*TP*CP*TP*TP*CP*GP*GP*CP*AP*AP*TP*T)-3') | polymer | 14 | 4246.8 | 1 | Mus musculus | ||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (A) | (3R)-3-[1-(3H-1lambda~4~,3-benzothiazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-2-benzofuran-1(3H)-one | non-polymer | 365.4 | 1 | Chemie (AE7) | |||
| 6 | F, G, H (A, E, F) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A: 147 - 507 (UniProt: Q8C6L5)
| PDB | External Database | Details |
|---|---|---|
| Ser 146 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 51385.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 430.8 | |
| All* | Total formula weight | 51816.7 |
