5XZB

Mouse cGAS bound to the inhibitor RU365

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cyclic GMP-AMP synthase	polymer	357	41970.5	1	UniProt (Q8C6L5) Pfam (PF03281) Pfam (PF20266) In PDB	Mus musculus (Mouse)	m-cGAS, 2'3'-cGAMP synthase, Mab-21 domain-containing protein 1
2	E	DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*G)-3')	polymer	15	4627.0	1		Mus musculus
3	F	DNA (5'-D(P*CP*GP*TP*CP*TP*TP*CP*GP*GP*CP*AP*AP*TP*T)-3')	polymer	14	4246.8	1		Mus musculus
4	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	A	(3R)-3-[1-(1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-2-benzofuran-1(3H)-one	non-polymer		346.3	1	Chemie (A9Y)
6		water	water		18.0	66	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	50844.3
Non-Polymers*	Number of molecules	2
	Total formula weight	411.7
All*	Total formula weight	51256.1

*Water molecules are not included.