5XY1
Crystal structure of Lyn kinase domain in complex with N-(1H-indazol-6-yl)-8-(piperidin-4-yloxy)-6-propylquinazolin-2-amine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase Lyn | polymer | 279 | 31797.5 | 1 | UniProt (P07948) Pfam (PF07714) In PDB | Homo sapiens (Human) | Lck/Yes-related novel protein tyrosine kinase,V-yes-1 Yamaguchi sarcoma viral related oncogene homolog,p53Lyn,p56Lyn |
2 | A | N-(1H-indazol-6-yl)-8-piperidin-4-yloxy-6-propyl-quinazolin-2-amine | non-polymer | 402.5 | 1 | Chemie (8H0) | |||
3 | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A: 239 - 512 (UniProt: P07948)
PDB | External Database | Details |
---|---|---|
Gly 234 | - | expression tag |
Ala 235 | - | expression tag |
Met 236 | - | expression tag |
Gly 237 | - | expression tag |
Ser 238 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 31797.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 402.5 | |
All* | Total formula weight | 32200.0 |