5XY1
Crystal structure of Lyn kinase domain in complex with N-(1H-indazol-6-yl)-8-(piperidin-4-yloxy)-6-propylquinazolin-2-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase Lyn | polymer | 279 | 31797.5 | 1 | UniProt (P07948) Pfam (PF07714) | Homo sapiens (Human) | Lck/Yes-related novel protein tyrosine kinase,V-yes-1 Yamaguchi sarcoma viral related oncogene homolog,p53Lyn,p56Lyn |
| 2 | B (A) | N-(1H-indazol-6-yl)-8-piperidin-4-yloxy-6-propyl-quinazolin-2-amine | non-polymer | 402.5 | 1 | Chemie (8H0) | |||
| 3 | C (A) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A: 239 - 512 (UniProt: P07948)
| PDB | External Database | Details |
|---|---|---|
| Gly 234 | - | expression tag |
| Ala 235 | - | expression tag |
| Met 236 | - | expression tag |
| Gly 237 | - | expression tag |
| Ser 238 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31797.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 402.5 | |
| All* | Total formula weight | 32200.0 |
