5XXK
Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | E3 ubiquitin-protein ligase Mdm2 | polymer | 122 | 13689.6 | 2 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
| 2 | C, D (C, D) | Hydrocarbon stapled peptide THC-SER-PHE-0EH-GLU-TYR-6CW-ALA-LEU-LEU-MK8-NH2 | polymer | 12 | 1500.2 | 2 | Phage display vector pTDisp | ||
| 3 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 124 | Chemie (HOH) |
Sequence modifications
A, B: 6 - 125 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly 4 | - | expression tag |
| Pro 5 | - | expression tag |
| Ala 62 | Met 62 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 30379.5 | |
| All* | Total formula weight | 30379.5 |
