5XVG
Crystal Structure of PAK4 in complex with inhibitor CZH226
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase PAK 4 | polymer | 293 | 33098.4 | 1 | UniProt (O96013) Pfam (PF00069) | Homo sapiens (Human) | p21-activated kinase 4,PAK-4 |
| 2 | B (A) | [6-chloranyl-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]-[(3R)-3-methylpiperazin-1-yl]methanone | non-polymer | 411.9 | 1 | Chemie (8FX) | |||
| 3 | C, D, E, F, G (A) | ETHANOL | non-polymer | 46.1 | 5 | Chemie (EOH) | |||
| 4 | H, I, J (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | K (A) | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence modifications
A: 300 - 591 (UniProt: O96013)
| PDB | External Database | Details |
|---|---|---|
| Ser 299 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33098.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 828.4 | |
| All* | Total formula weight | 33926.9 |
