5XOC

Crystal structure of human Smad3-FoxH1 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Mothers against decapentaplegic homolog 3	polymer	199	22463.5	1	UniProt (P84022) Pfam (PF03166)	Homo sapiens (Human)	hMAD-3,JV15-2,SMAD family member 3,hSMAD3
2	B (B)	Thioredoxin 1,Forkhead box protein H1	polymer	141	15437.6	1	UniProt (P0AA25) UniProt (O75593) Pfam (PF00085)	Escherichia coli (strain K12)	Trx-1,Forkhead activin signal transducer 1,hFAST-1,Forkhead activin signal transducer 2,Fast-2
3	C, D (A, B)	water	water		18.0	36	Chemie (HOH)

Sequence modifications

A: 220 - 416 (UniProt: P84022)

PDB	External Database	Details
Gly 218	-	expression tag
Pro 219	-	expression tag

B: 212 - 319 (UniProt: P0AA25)

PDB	External Database	Details
Met 205	-	initiating methionine
His 206	-	expression tag
His 207	-	expression tag
His 208	-	expression tag
His 209	-	expression tag
His 210	-	expression tag
His 211	-	expression tag
Gly 320	-	linker
Ser 321	-	linker

B: 322 - 345 (UniProt: O75593)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	37901.1
All*	Total formula weight	37901.1

*Water molecules are not included.