5XN1
HIV-1 reverse transcriptase Q151M:DNA:entecavir-triphosphate ternary complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Pol protein | polymer | 557 | 64033.4 | 2 | UniProt (D3XFN7) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) UniProt (by SIFTS) (P12497) In PDB | Human immunodeficiency virus 1 | |
| 2 | B, D | Pol protein | polymer | 444 | 51861.5 | 2 | UniProt (D3XFN7) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) UniProt (by SIFTS) (P12497) In PDB | Human immunodeficiency virus 1 | |
| 3 | E, F | 38-MER DNA aptamer | polymer | 38 | 11724.5 | 2 | synthetic construct | ||
| 4 | G | beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900003) | sucrose | ||
| 5 | A, C | [[(1R,3S,5S)-3-(2-azanyl-6-oxidanylidene-3H-purin-9-yl)-2-methylidene-5-oxidanyl-cyclopentyl]methoxy-oxidanyl-phosphory l] phosphono hydrogen phosphate | non-polymer | 517.2 | 2 | Chemie (ET9) | |||
| 6 | A, C | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 7 | B, D, F | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 8 | water | water | 18.0 | 269 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 555 (UniProt: D3XFN7)
B, D: 1 - 428 (UniProt: D3XFN7)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | expression tag |
| Val 0 | - | expression tag |
| Met 151 | Gln 250 | engineered mutation |
| Ser 162 | Cys 261 | engineered mutation |
| Ser 280 | Cys 379 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -15 | - | expression tag |
| Ala -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| Ala -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Glu -5 | - | expression tag |
| Val -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 162 | Cys 261 | engineered mutation |
| Ser 280 | Cys 379 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 255238.9 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 342.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1543.5 | |
| All* | Total formula weight | 257124.7 |
