5XGN
Crystal structure of EGFR 696-1022 T790M/C797S in complex with Go6976
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Epidermal growth factor receptor | polymer | 331 | 37634.5 | 2 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | A | 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole | non-polymer | 378.4 | 1 | Chemie (85X) | |||
| 3 | B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | water | water | 18.0 | 55 | Chemie (HOH) |
Sequence modifications
A, B: 696 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 692 | - | expression tag |
| Ala 693 | - | expression tag |
| Met 694 | - | expression tag |
| Gly 695 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Ser 797 | Cys 797 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75269.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 449.3 | |
| All* | Total formula weight | 75718.4 |
