5XAU

Crystal structure of integrin binding fragment of laminin-511

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Laminin subunit alpha-5	polymer	674	73414.2	2	UniProt (O15230) Pfam (PF06009) Pfam (PF00054) Pfam (PF02210) In PDB	Homo sapiens (Human)
2	B, E	Laminin subunit beta-1	polymer	74	8552.8	2	UniProt (P07942) In PDB	Homo sapiens (Human)
3	C, F	Laminin subunit gamma-1	polymer	83	9483.7	2	UniProt (P11047) In PDB	Homo sapiens (Human)
4	G	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	A, D	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
6	A, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	7	Chemie (NAG)
7		water	water		18.0	591	Chemie (HOH)

Sequence modifications

A, D: 2655 - 3327 (UniProt: O15230)

PDB	External Database	Details
Gly 2654	-	expression tag
Cys 2723	Ile 2723	engineered mutation

B, E: 1714 - 1786 (UniProt: P07942)

PDB	External Database	Details
Gly 1713	-	expression tag

C, F: 1528 - 1609 (UniProt: P11047)

PDB	External Database	Details
Gly 1527	-	expression tag
Cys 1585	Asp 1585	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	182901.4
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	9
	Total formula weight	1628.6
All*	Total formula weight	184954.4

*Water molecules are not included.