5X66
Human thymidylate synthase in complex with dUMP and methotrexate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Thymidylate synthase | polymer | 290 | 33254.1 | 6 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (Human) | TSase |
2 | A, B, C, D, E... | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 6 | Chemie (UMP) | |||
3 | A, B, C, D, E... | METHOTREXATE | non-polymer | 454.4 | 6 | Chemie (MTX) | |||
4 | water | water | 18.0 | 934 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 26 - 313 (UniProt: P04818)
PDB | External Database | Details |
---|---|---|
Ser 24 | - | expression tag |
Met 25 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 199524.8 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 4575.7 | |
All* | Total formula weight | 204100.5 |