5X3V

Structure of human SHMT2 protein mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine hydroxymethyltransferase, mitochondrial	polymer	496	55081.6	2	UniProt (P34897) Pfam (PF00464)	Homo sapiens (Human)	SHMT,Glycine hydroxymethyltransferase,Serine methylase
2	C, D, E, F, G... (A, B)	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
3	I, J (A, B)	water	water		18.0	64	Chemie (HOH)

Sequence modifications

A, B: 1 - 483 (UniProt: P34897)

PDB	External Database	Details
Arg 74	Lys 95	engineered mutation
Lys 484	-	expression tag
Leu 485	-	expression tag
Ala 486	-	expression tag
Ala 487	-	expression tag
Ala 488	-	expression tag
Leu 489	-	expression tag
Glu 490	-	expression tag
His 491	-	expression tag
His 492	-	expression tag
His 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	110163.1
Non-Polymers*	Number of molecules	6
	Total formula weight	576.4
All*	Total formula weight	110739.5

*Water molecules are not included.