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5X22

Crystal structure of Thermus thermophilus transcription initiation complex with GpA and CMPcPP

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, J, K
(A, B, K, L)
DNA-directed RNA polymerase subunit alphapolymer31535056.24UniProt (Q9Z9H6)
Pfam (PF01193)
Pfam (PF01000)
Pfam (PF03118)
UniProt (by SIFTS) (Q5SHR6)
Thermus thermophilusRNAP subunit alpha,RNA polymerase subunit alpha,Transcriptase subunit alpha
2C, L
(C, M)
DNA-directed RNA polymerase subunit betapolymer1119125436.52UniProt (Q8RQE9)
Pfam (PF04563)
Pfam (PF04561)
Pfam (PF04565)
Pfam (PF10385)
Pfam (PF00562)
Pfam (PF04560)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)RNAP subunit beta,RNA polymerase subunit beta,Transcriptase subunit beta
3D, M
(D, N)
DNA-directed RNA polymerase subunit beta'polymer1524170997.42UniProt (Q8RQE8)
Pfam (PF04997)
Pfam (PF21668)
Pfam (PF00623)
Pfam (PF04983)
Pfam (PF05000)
Pfam (PF04998)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)RNAP subunit beta',RNA polymerase subunit beta',Transcriptase subunit beta'
4E, N
(E, O)
DNA-directed RNA polymerase subunit omegapolymer9911533.32UniProt (Q72ID6)
Pfam (PF01192)
UniProt (by SIFTS) (Q8RQE7)
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)RNAP omega subunit,RNA polymerase omega subunit,Transcriptase subunit omega
5F, O
(F, P)
RNA polymerase sigma factor SigApolymer44350739.42UniProt (Q72L95)
Pfam (PF00140)
Pfam (PF04542)
Pfam (PF04539)
Pfam (PF04545)
UniProt (by SIFTS) (Q5SKW1)
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
6G, P
(G, Q)
promoter DNA template strandpolymer216480.22Thermus thermophilus
7H, Q
(H, R)
promoter DNA nontemplate strandpolymer278421.42Thermus thermophilus
8I, R
(I, S)
RNA (5'-R(*GP*A)-3')polymer2629.52Thermus thermophilus
9AA, BA, EA, FA, GA...
(F, L, N, P, B...)
MAGNESIUM IONnon-polymer24.312Chemie (MG)
10CA, DA, T, U
(N, D)
ZINC IONnon-polymer65.44Chemie (ZN)
11IA, Z
(N, D)
5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidinenon-polymer481.22Chemie (2TM)
Sequence modifications
F, P: 1 - 423 (UniProt: Q72L95)
PDBExternal DatabaseDetails
Met -19-initiating methionine
Gly -18-expression tag
Ser -17-expression tag
Ser -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
His -11-expression tag
His -10-expression tag
Ser -9-expression tag
Ser -8-expression tag
Gly -7-expression tag
Leu -6-expression tag
Val -5-expression tag
Pro -4-expression tag
Arg -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
His 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains18
Total formula weight888700.0
Non-Polymers*Number of molecules18
Total formula weight1515.7
All*Total formula weight890215.7
*Water molecules are not included.

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PDB entries from 2024-10-30

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