5X02
Crystal structure of the FLT3 kinase domain bound to the inhibitor FF-10101
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Receptor-type tyrosine-protein kinase FLT3 | polymer | 347 | 40010.5 | 1 | UniProt (P36888) Pfam (PF07714) | Homo sapiens (Human) | FL cytokine receptor,Fetal liver kinase-2,FLK-2,Fms-like tyrosine kinase 3,FLT-3,Stem cell tyrosine kinase 1,STK-1,FL cytokine receptor,Fetal liver kinase-2,FLK-2,Fms-like tyrosine kinase 3,FLT-3,Stem cell tyrosine kinase 1,STK-1 |
| 2 | B (A) | N-[(2S)-1-[5-[2-[(4-cyanophenyl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxidanylidene-propan-2-yl]-4-(dimethylamino)-N-methyl-but-2-enamide | non-polymer | 530.7 | 1 | Chemie (F6M) | |||
| 3 | C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F (A) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A: 564 - 710 (UniProt: P36888)
A: 711 - 958 (UniProt: P36888)
| PDB | External Database | Details |
|---|---|---|
| Gly 561 | - | expression tag |
| Pro 562 | - | expression tag |
| Gly 563 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40010.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 818.9 | |
| All* | Total formula weight | 40829.4 |
