5WS7
Crystal structure of human MTH1(G2K/C87A/C104S mutant) in complex with 2-oxo-dATP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 7,8-dihydro-8-oxoguanine triphosphatase | polymer | 156 | 17995.5 | 2 | UniProt (P36639) Pfam (PF00293) | Homo sapiens (Human) | 2-hydroxy-dATP diphosphatase,8-oxo-dGTPase,Nucleoside diphosphate-linked moiety X motif 1,Nudix motif 1 |
| 2 | C, F (A, B) | [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | non-polymer | 507.2 | 2 | Chemie (6U4) | |||
| 3 | D, E, G, H (A, B) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 492 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 156 (UniProt: P36639)
| PDB | External Database | Details |
|---|---|---|
| Lys 2 | Gly 43 | engineered mutation |
| Ala 87 | Cys 128 | engineered mutation |
| Ser 104 | Cys 145 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35990.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1106.3 | |
| All* | Total formula weight | 37097.2 |
