5WN4
APE1 exonuclease substrate complex with a C/T mismatch
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | DNA (5'-D(P*TP*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3') | polymer | 11 | 3334.2 | 1 | synthetic construct | ||
| 2 | B (D) | DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DV3))-3') | polymer | 10 | 3077.1 | 1 | synthetic construct | ||
| 3 | C (E) | DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3') | polymer | 21 | 6424.1 | 1 | synthetic construct | ||
| 4 | D, E (A, B) | DNA-(apurinic or apyrimidinic site) lyase | polymer | 276 | 31156.5 | 2 | UniProt (P27695) Pfam (PF03372) | Homo sapiens (Human) | APEX1, APEX nuclease,APEN,Apurinic-apyrimidinic endonuclease 1, APE-1, REF-1, Redox factor-1 |
| 5 | F, H, J (C, E, A) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 6 | G (D) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 7 | I, L (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 8 | K (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 9 | M, N, O, P, Q (C, D, E, A, B) | water | water | 18.0 | 182 | Chemie (HOH) |
Sequence modifications
A, B: 43 - 318 (UniProt: P27695)
| PDB | External Database | Details |
|---|---|---|
| Ala 138 | Cys 138 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 75148.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 268.6 | |
| All* | Total formula weight | 75417.0 |
