5WH5

Crystal structure of the PDE4D2 catalytic domain in complex with inhibitor (R)-Zl-n-91

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	polymer	327	37706.7	2	UniProt (Q08499) Pfam (PF00233)	Homo sapiens (Human)	DPDE3,PDE43
2	C, G (A, B)	1-[4-(difluoromethoxy)-3-{[(3R)-oxolan-3-yl]oxy}phenyl]-3-methylbutan-1-one	non-polymer		314.3	2	Chemie (R91)
3	D, H (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	E, F, I (A, B)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
5	J, K (A, B)	water	water		18.0	388	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75413.4
Non-Polymers*	Number of molecules	7
	Total formula weight	832.4
All*	Total formula weight	76245.8

*Water molecules are not included.