5WH5
Crystal structure of the PDE4D2 catalytic domain in complex with inhibitor (R)-Zl-n-91
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 327 | 37706.7 | 2 | UniProt (Q08499) Pfam (PF00233) In PDB | Homo sapiens (Human) | DPDE3,PDE43 |
| 2 | A, B | 1-[4-(difluoromethoxy)-3-{[(3R)-oxolan-3-yl]oxy}phenyl]-3-methylbutan-1-one | non-polymer | 314.3 | 2 | Chemie (R91) | |||
| 3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 5 | water | water | 18.0 | 388 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75413.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 832.4 | |
| All* | Total formula weight | 76245.8 |
