5WEO
Activated GluA2 complex bound to glutamate, cyclothiazide, and STZ in digitonin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit chimera | polymer | 1034 | 115502.0 | 4 | UniProt (P19491) UniProt (O88602) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00822) | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Neuronal voltage-gated calcium channel gamma-2 subunit,Stargazin,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2 |
| 2 | E, G, I, K (A, B, C, D) | GLUTAMIC ACID | non-polymer | 147.1 | 4 | Chemie (GLU) PubChem (611) PubChem (23327) PubChem (33032) | |||
| 3 | F, H, J, L (A, B, C, D) | CYCLOTHIAZIDE | non-polymer | 389.9 | 4 | Chemie (CYZ) PubChem (2910) PubChem (21550932) PubChem (177678892) PubChem (44582559) PubChem (657321) PubChem (52949708) PubChem (5288009) PubChem (6603794) PubChem (92143401) PubChem (92215537) PubChem (11972587) PubChem (98047042) PubChem (92142359) PubChem (98047041) PubChem (101691639) PubChem (5388988) PubChem (101691640) PubChem (131842006) |
Sequence modifications
A, B, C, D: 10 - 826 (UniProt: P19491)
A, B, C, D: 1001 - 1207 (UniProt: O88602)
| PDB | External Database | Details |
|---|---|---|
| Glu 241 | Asn 256 | engineered mutation |
| Leu 382 | Val 397 | engineered mutation |
| - | Leu 399 | deletion |
| - | Thr 400 | deletion |
| - | Glu 401 | deletion |
| - | Leu 402 | deletion |
| - | Pro 403 | deletion |
| - | Ser 404 | deletion |
| Glu 384 | Gly 405 | engineered mutation |
| Asp 385 | Asn 406 | engineered mutation |
| Gln 392 | Asn 413 | engineered mutation |
| Gly 827 | - | linker |
| Thr 828 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Asp 1047 | Asn 48 | conflict |
| Thr 1208 | - | expression tag |
| Gly 1209 | - | expression tag |
| Gly 1210 | - | expression tag |
| Leu 1211 | - | expression tag |
| Val 1212 | - | expression tag |
| Pro 1213 | - | expression tag |
| Arg 1214 | - | expression tag |
| Gly 1215 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 462007.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2148.0 | |
| All* | Total formula weight | 464155.9 |
