5WEO
Activated GluA2 complex bound to glutamate, cyclothiazide, and STZ in digitonin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit chimera | polymer | 1034 | 115502.0 | 4 | UniProt (P19491) UniProt (O88602) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00822) In PDB | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Neuronal voltage-gated calcium channel gamma-2 subunit,Stargazin,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2 |
2 | A, B, C, D | GLUTAMIC ACID | non-polymer | 147.1 | 4 | Chemie (GLU) | |||
3 | A, B, C, D | CYCLOTHIAZIDE | non-polymer | 389.9 | 4 | Chemie (CYZ) |
Sequence modifications
A, B, C, D: 10 - 826 (UniProt: P19491)
A, B, C, D: 1001 - 1207 (UniProt: O88602)
PDB | External Database | Details |
---|---|---|
Glu 241 | Asn 256 | engineered mutation |
Leu 382 | Val 397 | engineered mutation |
- | Leu 399 | deletion |
- | Thr 400 | deletion |
- | Glu 401 | deletion |
- | Leu 402 | deletion |
- | Pro 403 | deletion |
- | Ser 404 | deletion |
Glu 384 | Gly 405 | engineered mutation |
Asp 385 | Asn 406 | engineered mutation |
Gln 392 | Asn 413 | engineered mutation |
Gly 827 | - | linker |
Thr 828 | - | linker |
PDB | External Database | Details |
---|---|---|
Asp 1047 | Asn 48 | conflict |
Thr 1208 | - | expression tag |
Gly 1209 | - | expression tag |
Gly 1210 | - | expression tag |
Leu 1211 | - | expression tag |
Val 1212 | - | expression tag |
Pro 1213 | - | expression tag |
Arg 1214 | - | expression tag |
Gly 1215 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 462007.9 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2148.0 | |
All* | Total formula weight | 464155.9 |