5WE9
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 7b (SRI-29731)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Polymerase acidic protein | polymer | 187 | 21970.2 | 1 | UniProt (C3W5S0) In PDB | Influenza A virus | |
| 2 | A | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | A | 2-[(2S)-1-(2,6-difluorobenzene-1-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenylethyl)-1,6-dihydropyrimidine-4-carboxamide | non-polymer | 468.5 | 1 | Chemie (GY7) | |||
| 5 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A: 1 - 50 (UniProt: C3W5S0)
A: 73 - 196 (UniProt: C3W5S0)
A: 73 - 196 (UniProt: C3W5S0)
| PDB | External Database | Details |
|---|---|---|
| Gly 51 | - | linker |
| Gly 52 | - | linker |
| Ser 53 | - | linker |
| Ala 197 | - | expression tag |
| Ala 198 | - | expression tag |
| Ala 199 | - | expression tag |
| Glu 200 | - | expression tag |
| Leu 201 | - | expression tag |
| Ala 202 | - | expression tag |
| Leu 203 | - | expression tag |
| Val 204 | - | expression tag |
| Pro 205 | - | expression tag |
| Arg 206 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 21970.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 609.8 | |
| All* | Total formula weight | 22579.9 |
