5WC5
Structural insights into the potency of SK/IK channel positive modulators
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | Small conductance calcium-activated potassium channel protein 2 | polymer | 95 | 11240.3 | 1 | UniProt (Q9H2S1) Pfam (PF02888) In PDB | Homo sapiens (Human) | SKCa2,KCa2.2 |
| 2 | R | Calmodulin-1 | polymer | 146 | 16420.0 | 1 | UniProt (P0DP23) Pfam (PF13499) In PDB | Homo sapiens (Human) | |
| 3 | B, R | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | R | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 6 | R | 7-fluoro-3-(hydroxyamino)-2H-indol-2-one | non-polymer | 180.1 | 1 | Chemie (AJV) | |||
| 7 | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
B: 396 - 487 (UniProt: Q9H2S1)
R: 4 - 147 (UniProt: P0DP23)
| PDB | External Database | Details |
|---|---|---|
| Gly 395 | - | expression tag |
| Ala 409 | Asn 408 | engineered mutation |
| Leu 488 | - | expression tag |
| Glu 489 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 2 | - | expression tag |
| Ala 3 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27660.3 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 928.8 | |
| All* | Total formula weight | 28589.1 |
