5W9D

Estrogen Receptor Alpha Ligand Binding Domain C381S, C417S, C530S Mutant in Complex with Endoxifen

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Estrogen receptor	polymer	249	28355.2	2	UniProt (P03372) Pfam (PF00104)	Homo sapiens (Human)	ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
2	C, D (A, B)	Endoxifen	non-polymer		373.5	2	Chemie (9XY)
3	E, F (A, B)	water	water		18.0	615	Chemie (HOH)

Sequence modifications

A, B: 306 - 554 (UniProt: P03372)

PDB	External Database	Details
Ser 381	Cys 381	engineered mutation
Ser 417	Cys 417	engineered mutation
Ser 530	Cys 530	engineered mutation
Ser 536	Leu 536	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	56710.4
Non-Polymers*	Number of molecules	2
	Total formula weight	747.0
All*	Total formula weight	57457.4

*Water molecules are not included.