5W9D
Estrogen Receptor Alpha Ligand Binding Domain C381S, C417S, C530S Mutant in Complex with Endoxifen
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Estrogen receptor | polymer | 249 | 28355.2 | 2 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | A, B | Endoxifen | non-polymer | 373.5 | 2 | Chemie (9XY) | |||
| 3 | water | water | 18.0 | 615 | Chemie (HOH) |
Sequence modifications
A, B: 306 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 381 | Cys 381 | engineered mutation |
| Ser 417 | Cys 417 | engineered mutation |
| Ser 530 | Cys 530 | engineered mutation |
| Ser 536 | Leu 536 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 56710.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 747.0 | |
| All* | Total formula weight | 57457.4 |
