5W8T
Crystal structure of MERS-CoV papain-like protease in complex with the C-terminal domain of human ISG15
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, D | Ubiquitin-like protein ISG15 | polymer | 78 | 8870.2 | 2 | UniProt (P05161) Pfam (PF00240) In PDB | Homo sapiens (human) | Interferon-induced 15 kDa protein,Interferon-induced 17 kDa protein,IP17,Ubiquitin cross-reactive protein,hUCRP |
| 2 | A, C | ORF1ab | polymer | 322 | 35817.2 | 2 | UniProt (K0BWD0) Pfam (PF08715) UniProt (by SIFTS) (M4STU1) In PDB | Human betacoronavirus 2c EMC/2012 | |
| 3 | B, D | prop-2-en-1-amine | non-polymer | 57.1 | 2 | Chemie (AYE) | |||
| 4 | A, C | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 5 | A, D, C | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 6 | Chemie (MPD) | |||
| 6 | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
B, D: 80 - 156 (UniProt: P05161)
| PDB | External Database | Details |
|---|---|---|
| Met 79 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 89374.8 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1215.7 | |
| All* | Total formula weight | 90590.5 |
