5W8L

Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 59 and NADH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	L-lactate dehydrogenase A chain	polymer	332	36734.7	4	UniProt (P00338) Pfam (PF00056) Pfam (PF02866)	Homo sapiens (Human)	LDH-A,Cell proliferation-inducing gene 19 protein,LDH muscle subunit,LDH-M,Renal carcinoma antigen NY-REN-59
2	E, K, N, T (A, B, C, D)	1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE	non-polymer		665.4	4	Chemie (NAI)
3	F, L, O, U (A, B, C, D)	2-{3-([1,1'-biphenyl]-3-yl)-5-(cyclopropylmethyl)-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid	non-polymer		570.7	4	Chemie (9YA)
4	G, H, I, J, M... (A, B, C, D)	1,2-ETHANEDIOL	non-polymer		62.1	13	Chemie (EDO)
5	AA, BA, CA, Z (B, C, D, A)	water	water		18.0	1181	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	146938.7
Non-Polymers*	Number of molecules	21
	Total formula weight	5751.4
All*	Total formula weight	152690.1

*Water molecules are not included.