5W8K
Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 29 and NADH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | L-lactate dehydrogenase A chain | polymer | 332 | 36734.7 | 4 | UniProt (P00338) Pfam (PF00056) Pfam (PF02866) | Homo sapiens (Human) | LDH-A,Cell proliferation-inducing gene 19 protein,LDH muscle subunit,LDH-M,Renal carcinoma antigen NY-REN-59 |
| 2 | E, S, Y (A, C, D) | 2-{3-(3,4-difluorophenyl)-5-hydroxy-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid | non-polymer | 492.5 | 3 | Chemie (9Y7) | |||
| 3 | F, N, T, Z (A, B, C, D) | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 4 | Chemie (NAI) | |||
| 4 | AA, G, M, O, U (D, A, B, C) | MALONIC ACID | non-polymer | 104.1 | 5 | Chemie (MLA) | |||
| 5 | BA, CA, DA, H, I... (D, A, B, C) | GLYCEROL | non-polymer | 92.1 | 14 | Chemie (GOL) | |||
| 6 | EA, FA, GA, HA (A, B, C, D) | water | water | 18.0 | 1112 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 146938.7 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 5948.8 | |
| All* | Total formula weight | 152887.5 |
