5W8J
Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 29
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | L-lactate dehydrogenase A chain | polymer | 332 | 36734.7 | 4 | UniProt (P00338) Pfam (PF00056) Pfam (PF02866) | Homo sapiens (Human) | LDH-A,Cell proliferation-inducing gene 19 protein,LDH muscle subunit,LDH-M,Renal carcinoma antigen NY-REN-59 |
| 2 | E, F, L, O, P... (A, B, C, D) | 2-{3-(3,4-difluorophenyl)-5-hydroxy-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid | non-polymer | 492.5 | 6 | Chemie (9Y7) | |||
| 3 | G, K, M, N, R (A, B, C, D) | MALONIC ACID | non-polymer | 104.1 | 5 | Chemie (MLA) | |||
| 4 | H, I, Q, T, U (A, C, D) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 5 | Chemie (DMS) | |||
| 5 | J, V (A, D) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | W, X, Y, Z (A, B, C, D) | water | water | 18.0 | 1328 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 146938.7 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 4050.0 | |
| All* | Total formula weight | 150988.7 |
