5W8I
Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 23 and Zinc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | L-lactate dehydrogenase A chain | polymer | 332 | 36734.7 | 4 | UniProt (P00338) Pfam (PF00056) Pfam (PF02866) | Homo sapiens (Human) | LDH-A,Cell proliferation-inducing gene 19 protein,LDH muscle subunit,LDH-M,Renal carcinoma antigen NY-REN-59 |
| 2 | E, F, N, R, S (A, C, D) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 3 | G, O, T (A, C, D) | 2-[3-(3,4-difluorophenyl)-5-hydroxy-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid | non-polymer | 323.3 | 3 | Chemie (9YD) | |||
| 4 | H, K, P, U (A, B, C, D) | CITRIC ACID | non-polymer | 192.1 | 4 | Chemie (CIT) | |||
| 5 | I, L, Q, V (A, B, C, D) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
| 6 | J (B) | MALONIC ACID | non-polymer | 104.1 | 1 | Chemie (MLA) | |||
| 7 | M (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 8 | W, X, Y, Z (A, B, C, D) | water | water | 18.0 | 912 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 146938.7 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2574.1 | |
| All* | Total formula weight | 149512.7 |
