5W6G

Human antibody 6649 in complex with influenza hemagglutinin H1 Solomon Islands

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hemagglutinin HA1	polymer	334	37239.7	1	UniProt (A7UPX0) Pfam (PF00509) In PDB	Influenza A virus (A/Solomon Islands/3/2006(H1N1))
2	B	Hemagglutinin HA2	polymer	178	20356.6	1	UniProt (A7UPX0) Pfam (PF00509) In PDB	Influenza A virus (A/Solomon Islands/3/2006(H1N1))
3	H	6649 antibody heavy chain	polymer	230	24791.8	1	UniProt (S6B2B6) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
4	L	6649 antibody light chain	polymer	218	22901.3	1	UniProt (Q6GMX4) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
5	C	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
7	A	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
8	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
9		water	water		18.0	11	Chemie (HOH)

Sequence modifications

A: 5 - 330 (UniProt: A7UPX0)

PDB	External Database	Details
Ala -3	-	expression tag
Asp -2	-	expression tag
Pro -1	-	expression tag
Gly 0	-	expression tag
Tyr 1	-	expression tag
Leu 2	-	expression tag
Leu 3	-	expression tag
Glu 4	-	expression tag

B: 501 - 676 (UniProt: A7UPX0)

PDB	External Database	Details
Arg 677	-	expression tag
Ser 678	-	expression tag

H: 1 - 117 (PDB: 5W6G)
H: 118 - 230 (UniProt: S6B2B6)

PDB	External Database	Details
Gly 125	Ser 145	conflict
Val 148	Ala 168	conflict

L: 1 - 117 (PDB: 5W6G)
L: 118 - 218 (UniProt: Q6GMX4)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	105289.4
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	12
	Total formula weight	1645.4
All*	Total formula weight	107359.2

*Water molecules are not included.