5W5Y
RNA polymerase I Initial Transcribing Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | DNA-directed RNA polymerase I subunit RPA190 | polymer | 1664 | 186677.0 | 1 | UniProt (P10964) Pfam (PF04997) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | DNA-directed RNA polymerase I 190 kDa polypeptide,A190,DNA-directed RNA polymerase I largest subunit |
| 2 | B | DNA-directed RNA polymerase I subunit RPA135 | polymer | 1203 | 135910.3 | 1 | UniProt (P22138) Pfam (PF00562) Pfam (PF04560) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF06883) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | DNA-directed RNA polymerase I 135 kDa polypeptide,A135,DNA-directed RNA polymerase I polypeptide 2,RNA polymerase I subunit 2 |
| 3 | C | DNA-directed RNA polymerases I and III subunit RPAC1 | polymer | 335 | 37732.6 | 1 | UniProt (P07703) Pfam (PF01193) Pfam (PF01000) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | RNA polymerases I and III subunit AC1,C37,DNA-directed RNA polymerases I and III 40 kDa polypeptide,C40 |
| 4 | D | DNA-directed RNA polymerase I subunit RPA14 | polymer | 137 | 14599.1 | 1 | UniProt (P50106) Pfam (PF08203) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | A14,DNA-directed RNA polymerase I 14 kDa polypeptide |
| 5 | E | DNA-directed RNA polymerases I, II, and III subunit RPABC1 | polymer | 215 | 25117.1 | 1 | UniProt (P20434) Pfam (PF03871) Pfam (PF01191) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | RNA polymerases I,II,and III subunit ABC1,ABC27,DNA-directed RNA polymerases I,and III 27 kDa polypeptide |
| 6 | F | DNA-directed RNA polymerases I, II, and III subunit RPABC2 | polymer | 155 | 17931.8 | 1 | UniProt (P20435) Pfam (PF01192) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | RNA polymerases I,II,and III subunit ABC2,ABC23,DNA-directed RNA polymerases I,and III 23 kDa polypeptide |
| 7 | G | DNA-directed RNA polymerase I subunit RPA43 | polymer | 326 | 36264.9 | 1 | UniProt (P46669) Pfam (PF03876) Pfam (PF17875) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | A43,DNA-directed DNA-dependent RNA polymerase 36 kDa polypeptide |
| 8 | H | DNA-directed RNA polymerases I, II, and III subunit RPABC3 | polymer | 146 | 16525.4 | 1 | UniProt (P20436) Pfam (PF03870) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | RNA polymerases I,II,and III subunit ABC3,ABC14.4,ABC14.5,DNA-directed RNA polymerases I,and III 14.5 kDa polypeptide |
| 9 | I | DNA-directed RNA polymerase I subunit RPA12 | polymer | 125 | 13676.6 | 1 | UniProt (P32529) Pfam (PF02150) Pfam (PF01096) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | A12,A12.2,DNA-directed RNA polymerase I 13.7 kDa polypeptide |
| 10 | J | DNA-directed RNA polymerases I, II, and III subunit RPABC5 | polymer | 70 | 8290.7 | 1 | UniProt (P22139) Pfam (PF01194) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | RNA polymerases I,II,and III subunit ABC5,ABC10-beta,ABC8,DNA-directed RNA polymerases I,and III 8.3 kDa polypeptide |
| 11 | K | DNA-directed RNA polymerases I and III subunit RPAC2 | polymer | 142 | 16167.9 | 1 | UniProt (P28000) Pfam (PF13656) Pfam (PF01193) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | RNA polymerases I and III subunit AC2,AC19,DNA-directed RNA polymerases I and III 16 kDa polypeptide,RPA19 |
| 12 | L | DNA-directed RNA polymerases I, II, and III subunit RPABC4 | polymer | 70 | 7730.0 | 1 | UniProt (P40422) Pfam (PF03604) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | RNA polymerases I,II,and III subunit ABC4,ABC10-alpha |
| 13 | M | DNA-directed RNA polymerase I subunit RPA49 | polymer | 415 | 46721.7 | 1 | UniProt (Q01080) Pfam (PF06870) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | A49,DNA-directed RNA polymerase I 49 kDa polypeptide |
| 14 | N | DNA-directed RNA polymerase I subunit RPA34 | polymer | 233 | 26933.5 | 1 | UniProt (P47006) Pfam (PF08208) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | A34,DNA-directed DNA-dependent RNA polymerase 34.5 kDa polypeptide,A34.5 |
| 15 | O | RNA polymerase I-specific transcription initiation factor RRN6 | polymer | 894 | 100721.2 | 1 | UniProt (P32786) Pfam (PF10214) Pfam (PF20640) Pfam (PF20639) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | |
| 16 | P | RNA polymerase I-specific transcription initiation factor RRN7 | polymer | 514 | 60435.2 | 1 | UniProt (P40992) Pfam (PF11781) Pfam (PF20644) Pfam (PF20645) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | |
| 17 | Q | RNA polymerase I-specific transcription initiation factor RRN11 | polymer | 507 | 59334.3 | 1 | UniProt (Q04712) Pfam (PF04090) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | |
| 18 | R | RNA | polymer | 6 | 1915.2 | 1 | Saccharomyces cerevisiae S288c | ||
| 19 | S | non-template strand DNA | polymer | 54 | 16803.8 | 1 | Saccharomyces cerevisiae S288c | ||
| 20 | T | template strand DNA | polymer | 54 | 16360.5 | 1 | Saccharomyces cerevisiae S288c | ||
| 21 | A, B, I, J, L | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) |
Sequence modifications
O: -47 - 894 (UniProt: P32786)
| PDB | External Database | Details |
|---|---|---|
| Unk 4 | Glu 52 | SEE REMARK 999 |
| Unk 5 | Asp 53 | SEE REMARK 999 |
| Unk 6 | Ala 54 | SEE REMARK 999 |
| Unk 7 | Leu 55 | SEE REMARK 999 |
| Unk 8 | Asp 56 | SEE REMARK 999 |
| Unk 9 | Leu 57 | SEE REMARK 999 |
| Unk 10 | His 58 | SEE REMARK 999 |
| Unk 11 | Ile 59 | SEE REMARK 999 |
| Unk 12 | Val 60 | SEE REMARK 999 |
| Unk 13 | Val 61 | SEE REMARK 999 |
| Unk 14 | Lys 62 | SEE REMARK 999 |
| Unk 15 | Ser 63 | SEE REMARK 999 |
| Unk 16 | Leu 64 | SEE REMARK 999 |
| Unk 17 | Leu 65 | SEE REMARK 999 |
| Unk 18 | Cys 66 | SEE REMARK 999 |
| Unk 19 | Asp 67 | SEE REMARK 999 |
| Unk 20 | Thr 68 | SEE REMARK 999 |
| Unk 21 | Ala 69 | SEE REMARK 999 |
| Unk 22 | Ile 70 | SEE REMARK 999 |
| Unk 23 | Arg 71 | SEE REMARK 999 |
| Unk 24 | Tyr 72 | SEE REMARK 999 |
| Unk 25 | Ile 73 | SEE REMARK 999 |
| Unk 26 | Ser 74 | SEE REMARK 999 |
| Unk 27 | Asp 75 | SEE REMARK 999 |
| Unk 28 | Asp 76 | SEE REMARK 999 |
| Unk 41 | Tyr 145 | SEE REMARK 999 |
| Unk 42 | Ile 146 | SEE REMARK 999 |
| Unk 43 | Pro 147 | SEE REMARK 999 |
| Unk 44 | Ser 148 | SEE REMARK 999 |
| Unk 45 | Asp 149 | SEE REMARK 999 |
| Unk 46 | Leu 150 | SEE REMARK 999 |
| Unk 47 | Leu 151 | SEE REMARK 999 |
| Unk 48 | Arg 152 | SEE REMARK 999 |
| Unk 49 | Asn 153 | SEE REMARK 999 |
| Unk 50 | Leu 154 | SEE REMARK 999 |
| Unk 51 | Asp 155 | SEE REMARK 999 |
| Unk 52 | Asp 156 | SEE REMARK 999 |
| Unk 53 | Thr 157 | SEE REMARK 999 |
| Unk 54 | Leu 158 | SEE REMARK 999 |
| Unk 55 | Gln 159 | SEE REMARK 999 |
| Unk 56 | Glu 160 | SEE REMARK 999 |
| Unk 57 | Ser 161 | SEE REMARK 999 |
| Unk 58 | Thr 162 | SEE REMARK 999 |
| Unk 59 | Asn 163 | SEE REMARK 999 |
| Unk 60 | Ser 164 | SEE REMARK 999 |
| Unk 61 | Ser 165 | SEE REMARK 999 |
| Unk 62 | Arg 166 | SEE REMARK 999 |
| Unk 63 | Pro 167 | SEE REMARK 999 |
| Unk 64 | Met 168 | SEE REMARK 999 |
| Unk 65 | Gln 169 | SEE REMARK 999 |
| Unk 66 | Asp 170 | SEE REMARK 999 |
| Unk 67 | Ala 171 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 20 |
| Total formula weight | 845848.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 392.5 | |
| All* | Total formula weight | 846241.1 |
