5W5W
HIV Protease (PR) in open form with Mg2+ in active site and HIVE-9 in eye site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HIV-1 protease | polymer | 99 | 10767.7 | 2 | UniProt (Q8Q8V9) UniProt (by SIFTS) (P03366) | Human immunodeficiency virus 1 | |
| 2 | C (A) | benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate | non-polymer | 909.1 | 1 | BIRD (PRD_000434) Chemie (3TL) | |||
| 3 | D (A) | 4-methyl-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}carbamoyl)benzene-1-sulfonamide | non-polymer | 443.4 | 1 | Chemie (HV9) | |||
| 4 | E (B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | F (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: Q8Q8V9)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 10 | conflict |
| Ile 33 | Leu 36 | conflict |
| Ile 63 | Pro 66 | conflict |
| Ala 67 | Cys 70 | conflict |
| Ala 95 | Cys 98 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21535.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1430.7 | |
| All* | Total formula weight | 22966.1 |
