5W5Q
MAP4K4 in complex with inhibitor compound 12 (N3-methyl-10-(3-methyl-3-(5-methyloxazol-2-yl)but-1-yn-1-yl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2,3-dicarboxamide)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Mitogen-activated protein kinase kinase kinase kinase 4 | polymer | 332 | 37870.1 | 2 | UniProt (O95819) Pfam (PF00069) In PDB | Homo sapiens (Human) | HPK/GCK-like kinase HGK,MAPK/ERK kinase kinase kinase 4,MEKKK 4,Nck-interacting kinase |
| 2 | A | (5s,7s)-N~3~-methyl-10-[3-methyl-3-(5-methyl-1,3-oxazol-2-yl)but-1-yn-1-yl]-6,7-dihydro-5H-5,7-methanoimidazo[2,1-a][2]benzazepine-2,3-dicarboxamide | non-polymer | 443.5 | 1 | Chemie (9X4) | |||
| 3 | water | water | 18.0 | 214 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 328 (UniProt: O95819)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Gly 329 | - | expression tag |
| Asn 330 | - | expression tag |
| Ser 331 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75740.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 443.5 | |
| All* | Total formula weight | 76183.7 |
