5W5O

Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Receptor-interacting serine/threonine-protein kinase 2	polymer	310	35623.9	16	UniProt (O43353) Pfam (PF07714) In PDB	Homo sapiens (Human)	CARD-containing interleukin-1 beta-converting enzyme-associated kinase,CARD-containing IL-1 beta ICE-kinase,RIP-like-interacting CLARP kinase,Receptor-interacting protein 2,RIP-2,Tyrosine-protein kinase RIPK2
2	K, L, M, N, O...	4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine	non-polymer		507.0	16	Chemie (9XA)
3		water	water		18.0	304	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	569982.6
Non-Polymers*	Number of molecules	16
	Total formula weight	8112.8
All*	Total formula weight	578095.3

*Water molecules are not included.