5W5O
Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Receptor-interacting serine/threonine-protein kinase 2 | polymer | 310 | 35623.9 | 16 | UniProt (O43353) Pfam (PF07714) | Homo sapiens (Human) | CARD-containing interleukin-1 beta-converting enzyme-associated kinase,CARD-containing IL-1 beta ICE-kinase,RIP-like-interacting CLARP kinase,Receptor-interacting protein 2,RIP-2,Tyrosine-protein kinase RIPK2 |
| 2 | AA, BA, CA, DA, EA... (K, L, M, N, O...) | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | non-polymer | 507.0 | 16 | Chemie (9XA) | |||
| 3 | GA, HA, IA, JA, KA... (A, B, C, D, E...) | water | water | 18.0 | 304 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 569982.6 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 8112.8 | |
| All* | Total formula weight | 578095.3 |
