5W5M
Crystal structure of human IgG4-Sigma1 Fc fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Immunoglobulin heavy constant gamma 4 | polymer | 223 | 25030.2 | 2 | UniProt (P01861) Pfam (PF07654) | Homo sapiens (Human) | Ig gamma-4 chain C region |
| 2 | C, D (C, D) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 2 | In PDB GlyTouCan (G27919IH) | |||
| 3 | E, F (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | G (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 215 | Chemie (HOH) |
Sequence modifications
A, B: 226 - 447 (UniProt: P01861)
| PDB | External Database | Details |
|---|---|---|
| Thr 225 | - | expression tag |
| Pro 228 | Ser 108 | engineered mutation |
| Ala 234 | Phe 114 | engineered mutation |
| Ala 235 | Leu 115 | engineered mutation |
| Ala 237 | Gly 117 | engineered mutation |
| Ser 238 | Pro 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 50060.3 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 3251.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 243.2 | |
| All* | Total formula weight | 53554.6 |
