5W3I

Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6e (SRI-29685)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Polymerase acidic protein	polymer	201	23653.9	1	UniProt (C3W5S0)	Influenza A virus
2	B, C (A)	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
3	D (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	E (A)	5-hydroxy-N-(2-methoxyethyl)-6-oxo-2-[(2S)-1-(phenoxyacetyl)pyrrolidin-2-yl]-1,6-dihydropyrimidine-4-carboxamide	non-polymer		416.4	1	Chemie (GY5)
5	F (A)	water	water		18.0	80	Chemie (HOH)

Sequence modifications

A: 1 - 50 (UniProt: C3W5S0)
A: 73 - 196 (UniProt: C3W5S0)

PDB	External Database	Details
Gly 51	-	linker
Gly 52	-	linker
Ser 53	-	linker
Ala 197	-	expression tag
Ala 198	-	expression tag
Ala 199	-	expression tag
Glu 200	-	expression tag
Leu 201	-	expression tag
Ala 202	-	expression tag
Leu 203	-	expression tag
Val 204	-	expression tag
Pro 205	-	expression tag
Arg 206	-	expression tag
Gly 207	-	expression tag
Ser 208	-	expression tag
Ser 209	-	expression tag
Ala 210	-	expression tag
His 211	-	expression tag
His 212	-	expression tag
His 213	-	expression tag
His 214	-	expression tag
His 215	-	expression tag
His 216	-	expression tag
His 217	-	expression tag
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	23653.9
Non-Polymers*	Number of molecules	4
	Total formula weight	618.4
All*	Total formula weight	24272.3

*Water molecules are not included.