5W38
1.80A resolution structure of human IgG3 Fc (N392K)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Immunoglobulin heavy constant gamma 3 | polymer | 223 | 25223.7 | 2 | UniProt (P01860) Pfam (PF07654) | Homo sapiens (Human) | HDC,Heavy chain disease protein,Ig gamma-3 chain C region |
| 2 | C, D (C, D) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 3 | E (A) | CITRATE ANION | non-polymer | 189.1 | 1 | Chemie (FLC) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 351 | Chemie (HOH) |
Sequence modifications
A, B: 225 - 447 (UniProt: P01860)
| PDB | External Database | Details |
|---|---|---|
| Thr 225 | Pro 155 | conflict |
| Phe 296 | Tyr 226 | conflict |
| Lys 392 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 50447.5 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1173.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 189.1 | |
| All* | Total formula weight | 51809.7 |
