5W1X

Crystal Structure of Humanpapillomavirus18 (HPV18) Capsid L1 Pentamers Bound to Heparin Oligosaccharides

Replaces:  3OFL

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Major capsid protein L1	polymer	427	47478.0	15	UniProt (Q5G244) Pfam (PF00500) UniProt (by SIFTS) (P06794)	Human papillomavirus type 18
2	AA, DA, IA, JA, KA... (a, d, i, j, k...)	2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-alpha-D-glucopyranose	branched		500.4	19	In PDB GlyTouCan (G75183WV)
3	BA, CA, GA, HA, PA... (b, c, g, h, p...)	2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-alpha-D-glucopyranose	branched		982.8	9	In PDB GlyTouCan (G12683PR)
4	EA (e)	2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-alpha-D-glucopyranose	branched		1465.2	1	In PDB GlyTouCan (G29325GF)
5	FA (f)	2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-alpha-D-glucopyranose	branched		2430.0	1	In PDB GlyTouCan (G59499PQ)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L, M, N, O: 21 - 404 (UniProt: Q5G244)

PDB	External Database	Details
Ala 20	-	expression tag
Asp 47	Asn 98	engineered mutation
Ser 175	Cys 226	engineered mutation
Gln 393	His 444	engineered mutation

A, B, C, D, E, F, G, H, I, J, K, L, M, N, O: 438 - 474 (UniProt: Q5G244)

PDB	External Database	Details
Gly 433	-	linker
Gly 434	-	linker
Ser 435	-	linker
Gly 436	-	linker
Gly 437	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	15
	Total formula weight	712170.5
Branched	Number of molecules	30
	Total formula weight	22248.1
All*	Total formula weight	734418.6

*Water molecules are not included.