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5W0C

Cytochrome P450 (CYP) 2C9 TCA007 Inhibitor Complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Cytochrome P450 2C9polymer47754322.91UniProt (P11712)
Pfam (PF00067)
Homo sapiens (Human)(R)-limonene 6-monooxygenase,(S)-limonene 6-monooxygenase,(S)-limonene 7-monooxygenase,CYPIIC9,Cholesterol 25-hydroxylase,Cytochrome P-450MP,Cytochrome P450 MP-4,Cytochrome P450 MP-8,Cytochrome P450 PB-1,S-mephenytoin 4-hydroxylase
2B
(A)
PROTOPORPHYRIN IX CONTAINING FEnon-polymer616.51Chemie (HEM)
3C
(A)
ethyl {2-[([1,3]thiazolo[4,5-c]pyridine-2-carbonyl)amino]thiophene-3-carbonyl}carbamatenon-polymer376.41Chemie (9W6)
4D
(A)
GLYCEROLnon-polymer92.11Chemie (GOL)
5E
(A)
waterwater18.0211Chemie (HOH)
Sequence modifications
A: 23 - 489 (UniProt: P11712)
PDBExternal DatabaseDetails
Met 18-initiating methionine
Ala 19-expression tag
Lys 20-expression tag
Lys 21-expression tag
Thr 22-expression tag
Ile 490-expression tag
His 491-expression tag
His 492-expression tag
His 493-expression tag
His 494-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight54322.9
Non-Polymers*Number of molecules3
Total formula weight1085.0
All*Total formula weight55407.9
*Water molecules are not included.

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PDB entries from 2025-07-16

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