5VZ6
HIV Reverse Transcriptase complexed with (E)-3-(pyrimidin-2-yl)-N-(5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrazol-3-yl)acrylamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HIV Reverse Transcriptase | polymer | 563 | 64895.3 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus type 1 (HIV-1) | p66 RT, Exoribonuclease H |
| 2 | B (B) | HIV Reverse Transcriptase | polymer | 443 | 51731.4 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus type 1 (HIV-1) | p51 RT |
| 3 | C (A) | 3-(pyrimidin-2-yl)-N-[3-(5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrazol-5-yl]propanamide | non-polymer | 347.4 | 1 | Chemie (9TV) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
A: -2 - 560 (UniProt: P04585)
B: -2 - 440 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Met -2 | Leu 585 | conflict |
| Ser 0 | Phe 587 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -2 | Leu 585 | conflict |
| Ser 0 | Phe 587 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 116626.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 347.4 | |
| All* | Total formula weight | 116974.1 |
