5VYQ

Crystal structure of the N-formyltransferase Rv3404c from mycobacterium tuberculosis in complex with YDP-Qui4N and folinic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Uncharacterized protein	polymer	255	29033.7	2	UniProt (R4MIX2) Pfam (PF00551) Pfam (PF18216) UniProt (by SIFTS) (P9WKZ3) In PDB	Mycobacterium tuberculosis CAS/NITR204
2	A	N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid	non-polymer		473.4	1	Chemie (FON)
3	A	dTDP-4-amino-4,6-dideoxyglucose	non-polymer		547.3	1	Chemie (0FX)
4	A, B	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
5	A, B	SODIUM ION	non-polymer		23.0	4	Chemie (NA)
6	A, B	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
7	A, B	3-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]PROPANE-1-SULFONIC ACID	non-polymer		252.3	2	Chemie (EP1)
8	A	LITHIUM ION	non-polymer		6.9	1	Chemie (LI)
9	B	THYMIDINE-5'-DIPHOSPHATE	non-polymer		402.2	1	Chemie (TYD)
10	B	POTASSIUM ION	non-polymer		39.1	1	Chemie (K)
11		water	water		18.0	666	Chemie (HOH)

Sequence modifications

A, B: 3 - 235 (UniProt: R4MIX2)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Arg -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
His 0	-	expression tag
Met 1	-	expression tag
Val 2	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58067.5
Non-Polymers*	Number of molecules	18
	Total formula weight	2420.3
All*	Total formula weight	60487.8

*Water molecules are not included.