5VX3

Bcl-xL in complex with Bim-h3Pc-RT

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	Bcl-2-like protein 1	polymer	158	17918.0	4	UniProt (Q07817) Pfam (PF02180) Pfam (PF00452)	Homo sapiens (Human)	Bcl2-L-1,Apoptosis regulator Bcl-X,Bcl2-L-1,Apoptosis regulator Bcl-X
2	B, D, F, H (B, D, F, H)	Bcl-2-like protein 11	polymer	26	3241.6	4	UniProt (O43521) Pfam (PF08945)	Homo sapiens	Bcl2-L-11,Bcl2-interacting mediator of cell death
3	I, J, K, L, M... (A, C, E, F, G...)	1,2-ETHANEDIOL	non-polymer		62.1	13	Chemie (EDO)
4	AA, BA, CA, V, W... (F, G, H, A, B...)	water	water		18.0	415	Chemie (HOH)

Sequence modifications

A, C, E, G: 1 - 26 (UniProt: Q07817)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
Leu -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

A, C, E, G: 83 - 209 (UniProt: Q07817)
B, D, F, H: 83 - 108 (UniProt: O43521)

PDB	External Database	Details
Arg 89	Trp 147	engineered mutation
Thr 104	Tyr 162	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	84638.4
Non-Polymers*	Number of molecules	13
	Total formula weight	806.9
All*	Total formula weight	85445.3

*Water molecules are not included.