5VX2

Mcl-1 in complex with Bim-h3Pc-RT

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Induced myeloid leukemia cell differentiation protein Mcl-1 homolog,Induced myeloid leukemia cell differentiation protein Mcl-1 chimera	polymer	162	18227.6	2	UniProt (P97287) UniProt (Q07820) Pfam (PF00452)	Mus musculus (Mouse)	Bcl-2-related protein EAT/mcl1,Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT
2	B, D (B, D)	Bcl-2-like protein 11	polymer	26	3241.6	2	UniProt (O43521) Pfam (PF08945)	Homo sapiens	Bcl2-L-11,Bcl2-interacting mediator of cell death
3	E, F, G (A, C)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
4	H, I, J, K (A, B, C, D)	water	water		18.0	211	Chemie (HOH)

Sequence modifications

A, C: 171 - 208 (UniProt: P97287)

PDB	External Database	Details
Gly 166	-	expression tag
Pro 167	-	expression tag
Leu 168	-	expression tag
Gly 169	-	expression tag
Ser 170	-	expression tag

A, C: 209 - 327 (UniProt: Q07820)
B, D: 51 - 76 (UniProt: O43521)

PDB	External Database	Details
Arg 57	Trp 147	engineered mutation
Thr 72	Tyr 162	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	42938.5
Non-Polymers*	Number of molecules	3
	Total formula weight	186.2
All*	Total formula weight	43124.7

*Water molecules are not included.